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  • Title: Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin.
    Author: Taylor EC, Harrington PJ, Fletcher SR, Beardsley GP, Moran RG.
    Journal: J Med Chem; 1985 Jul; 28(7):914-21. PubMed ID: 4009615.
    Abstract:
    Total syntheses from pyridine precursors of 5,10-dideazaaminopterin (1) and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin (2) are described. These compounds exhibit significant in vivo activity against L1210 leukemia that is comparable to that observed with methotrexate.
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