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  • Title: Treatment of blood hyperviscosity with calcium dobesilate in patients with diabetic retinopathy.
    Author: Benarroch IS, Brodsky M, Rubinstein A, Viggiano C, Salama EA.
    Journal: Ophthalmic Res; 1985; 17(3):131-8. PubMed ID: 4011126.
    Abstract:
    This double-blind randomized trial was carried out on 37 patients with diabetic retinopathy and blood hyperviscosity. 19 patients received calcium dobesilate in capsules of 500 mg 3 times daily for 3 months and 18 patients took 3 placebo capsules daily during the same period. Calcium dobesilate was found to reduce whole-blood viscosity in a statistically significant manner which was accompanied by a diminution of the albumin/globulin ratio and a significant reduction of fibrinogen and cholesterol levels. A statistically significant diminution of capillary fragility was also observed in the calcium dobesilate-treated group. These results indicate that calcium dobesilate, by restoring the integrity of the microvessels, and by lowering blood viscosity, could act favorably on the evolution of diabetic retinopathy.
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