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  • Title: [Circadian rhythm of 3-methoxy-4-hydroxymandelic acid and 3-methoxy-4-hydroxyphenylacetic acid in the urine].
    Author: Vorbrodt B, Krause E, Weinert D.
    Journal: Pharmazie; 1985 Apr; 40(4):264-6. PubMed ID: 4011661.
    Abstract:
    The excretion of the catecholamine-metabolites 3-methoxy-4-hydroxymandelic acid and 3-methoxy-4-hydroxy-phenylacetic acid shows circadian variation. In applying the cosinoranalysis, we tested the normal process of the variation over 3 d and found partly significant circadian rhythms of the excretions with the maxima occurring in the second part of the day to the evening hours and the minima occurring at night. By prescribing the course of the day (fixed time of food intake as well as of sleeping) effects of synchronisation could be found from d 1 to 3. The possible importance of these circadian oscillations for an early or differential diagnosis and the question of the reduction and optimization of the time necessary for collecting urine are discussed.
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