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  • Title: Histamine and collagen levels in the lathyritic chick embryos after administration of 48/80.
    Author: Dabrowski R, Szczepanowska A.
    Journal: Agents Actions; 1985 Apr; 16(3-4):277-8. PubMed ID: 4013915.
    Abstract:
    The studies were undertaken to investigate the influence of compound 48/80 on histamine (Hi) and collagen levels of chick embryos after administration of lathyrogen factor, beta-aminopropionitrile (BAPN). Hi and soluble collagen levels in bones (tibia and femur) and skin were significantly higher in the embryos treated with BAPN. Compound 48/80 administered together with BAPN lowered Hi and soluble collagen in the bones and skin as compared with the embryos treated with BAPN alone. Both, in the skin and bones, 48/80 was found to be a protective factor against the changes in biosynthesis of collagen.
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