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  • Title: Tobacco constituents are mitogenic for arterial smooth-muscle cells.
    Author: Becker CG, Hajjar DP, Hefton JM.
    Journal: Am J Pathol; 1985 Jul; 120(1):1-5. PubMed ID: 4014438.
    Abstract:
    Tobacco glycoprotein (TGP) purified from flue-cured tobacco leaves, tar-derived material (TAR), the water soluble, nondialyzable, delipidized extract of cigarette smoke condensate, rutin-bovine serum albumin conjugates, quercetin, and chlorogenic acid are mitogenic for bovine aortic smooth-muscle cells, but not adventitial fibroblasts. The mitogenicity appears to depend on polyphenol epitopes on carrier molecules. Ellagic acid, another plant polyphenol, inhibited arterial smooth-muscle proliferation. These results suggest that a number of ubiquitous, plant-derived substances may influence smooth-muscle cell proliferation in the arterial wall.
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