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  • Title: Isolation, amino acid sequence, synthesis, and biological activity of some oligopeptides from porcine spinal cord.
    Author: Hsi KL, Chen RL, Chen ZG, Zhang HL, Lu YA, Guo SY, Wu SX, Tsou K.
    Journal: Arch Biochem Biophys; 1985 Jul; 240(1):178-83. PubMed ID: 4015098.
    Abstract:
    Four oligopeptides, designated SCP-3, SCP-4, SCP-5, and SCP-6, have been isolated and purified to homogeneity from porcine spinal cord. The amino acid sequences have been determined as pyroGlu-Gly, pyroGlu-Gly-Gly, Met-Met-Gly, and Asp-Ala-Gly-Ala-Gly, respectively. All of these peptides have been synthesized by conventional liquid-phase or solid-phase methods. The synthetic and extracted peptides showed identical behavior in a reverse-phase high-performance liquid chromatography system. SCP-3 and SCP-4 exhibited some significant inhibitory activity on the electrical stimulation-induced contractions of longitudinal muscle strip of guinea pig ileum, and SCP-5 showed some stimulating effect on the same preparation. The physiological significance of these purified peptides is being investigated.
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