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  • Title: Acute effects of tumor-promoting phorbol esters on hepatic intermediary metabolism.
    Author: Vaartjes WJ, de Haas CG.
    Journal: Biochem Biophys Res Commun; 1985 Jun 28; 129(3):721-6. PubMed ID: 4015651.
    Abstract:
    In hepatocytes isolated from meal-fed rats, phorbol 12-myristate 13-acetate as well as phorbol 12,13-didecanoate stimulated de novo fatty acid synthesis in a dose-dependent manner. Moreover, phorbol 12-myristate 13-acetate inhibited ketogenesis from exogenous oleate, but slightly enhanced oleate esterification. The stimulation of esterification was more pronounced with endogenously synthesized fatty acids. In hepatocytes from 24h-starved rats a moderate stimulation of gluconeogenesis and ureogenesis was observed with glutamine as substrate. It is concluded that tumor-promoting phorbol esters mimic the short-term effects of insulin on hepatic fatty acid metabolism.
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