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  • Title: Partial purification of the receptor protein essential for import of pre-ornithine aminotransferase into mitochondria.
    Author: Ono H, Tuboi S.
    Journal: Biochem Int; 1985 Mar; 10(3):351-7. PubMed ID: 4015663.
    Abstract:
    The isolated mitochondrial outer membrane fraction strongly inhibits the import of pre-ornithine aminotransferase, but other membranes such as rough microsomes did not. This inhibition seems to be caused by a receptor in the isolated outer membrane which binds competitively pre-ornithine aminotransferase. The mitochondrial outer membrane could be solubilized using detergent. And a receptor for pre-ornithine aminotransferase was partially purified by ammonium sulfate fractionation followed by column chromatography on Sephacryl S-300. Liposomes reconstituted from the partially purified receptor and lecithin could inhibit the import of pre-ornithine aminotransferase into mitochondria and bind the precursor.
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