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  • Title: Preparation and properties of ryodipine, an effective antihypertensive agent.
    Author: Kastron VV, Dubur GJ, Shatz VD, Yagupolsky LM.
    Journal: Arzneimittelforschung; 1985; 35(4):668-72. PubMed ID: 4015732.
    Abstract:
    A novel effective antihypertensive agent, 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(o-difluoromethoxyphenyl++ +)-1,4-dihydropyridine (ryodipine, PP-1466) has been obtained. A method for ryosidine synthesis has been developed, side products of PP-1466 synthesis have been isolated and identified. Special characteristics (IRS, UVS, NMR, MS) and chromatography data (TLC, HPLC) are cited.
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