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  • Title: Neoplastic angioendotheliosis. Immunohistochemical and electron microscopic findings in three cases.
    Author: Kitagawa M, Matsubara O, Song SY, Kurashima C, Okeda R, Kasuga T.
    Journal: Cancer; 1985 Sep 01; 56(5):1134-43. PubMed ID: 4016702.
    Abstract:
    Three cases of neoplastic angioendotheliosis (NAE) presenting with central nervous system (CNS) disease but no skin lesions are described. The histogenesis of the neoplastic cells is discussed. Microscopic examination showed accumulation of neoplastic cells in the vascular system throughout the body and their extravascular proliferation in several organs. Electron microscopic and immunohistochemical studies revealed the presence of Weibel-Palade bodies and factor VIII-related antigen in intravascular and extravascular neoplastic cells in two of the three cases. In the first case the neoplastic cells did not have any T-cell markers. However, in one case no specific markers were found in the neoplastic cells by electron microscopic, enzyme histochemical, or immunohistochemical examination. These findings, although supporting the endothelial origin of the neoplastic cells, indicate the need for further consideration of whether NAE is actually a single disease entity or several different diseases.
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