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  • Title: Effects of spermine on transferrin and iron uptake by reticulocytes: II. Changes in intravesicular pH.
    Author: Loh TT, Chan RY, Fong WF.
    Journal: Cell Biol Int Rep; 1985 May; 9(5):495-500. PubMed ID: 4016967.
    Abstract:
    An increase in extracellular spermine concentration brought about a progressive rise in intralysosomal pH in rabbit reticulocytes. Since intracellular release of iron from transferrin is believed to involve the protonation of the iron-transferrin complex, the rise in intralysomal pH could account for the inhibitory effect of spermine on iron uptake. The inhibition could be reversed if spermine was removed by washing. As a result of spermine treatment, more acid-labile N-terminal monoferric transferrin and less apotransferrin were released from the cell. These results are consistant with the protonation theory of iron release.
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