These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of corticosteroids on electrolyte transport of the isolated human and rabbit lens.
    Author: Kana JS, Wiederholt M.
    Journal: Curr Eye Res; 1985 Apr; 4(4):461-5. PubMed ID: 4017635.
    Abstract:
    In the isolated human lens, short circuit current was inhibited by pharmacological concentrations of 6-methylprednisolone and opacities occurred in the posterior subcapsular region in some lenses. The effect was seen only when the anterior (epithelial) surface of the lens was exposed. There was an increase of the short circuit current in the rabbit lens by 6-methyl-prednisolone and the lenses remained clear. Methylprednisolone effects were seen in spite of Na-K-ATPase inhibition by ouabain. Aldosterone had no effect on the translenticular potential difference, short circuit current and transparency. The data are discussed with respect to corticosteroid receptors in the lens epithelium and to the pathogenesis of steroid-associated cataract in man.
    [Abstract] [Full Text] [Related] [New Search]