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  • Title: Alterations in CFU-GM growth in preleukaemic and leukaemic AKR/J mice.
    Author: Alonso MC, Torres A, Solana R, Manzanares MR, Garcia-Castellano JM, Peña J.
    Journal: Folia Biol (Praha); 1985; 31(3):193-9. PubMed ID: 4018306.
    Abstract:
    The behaviour of committed CFU-GM bone marrow cells was investigated in leukaemic and preleukaemic AKR/J mice. The number of bone marrow CFU-GM decreased in the leukaemic stage of spontaneous AKR/J leukaemia. The addition of AKR/J leukaemic cells inhibited CFU-GM growth from normal target bone marrow. The bone marrow CFU-GM growth was also reduced in late preleukaemic AKR/J mice, whereas no modification in the CFU-GM number in early preleukaemic animals was found.
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