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  • Title: HLA and lymphocyte histamine sensitivity in mastocytosis.
    Author: Olafsson JH, Roupe G, Rydberg L.
    Journal: Int Arch Allergy Appl Immunol; 1985; 77(4):430-2. PubMed ID: 4018885.
    Abstract:
    HLA-ABC and DR typing was performed on 50 patients with mastocytosis. Lymphocyte stimulation with concanavalin A has earlier been performed in 22 of these patients. No phenotypic aberrations were detected in the patient group. 8 patients had the HLA-B12 phenotype. Lymphocytes from the HLA-B12 phenotype stimulated with a lymphocyte mitogen have earlier been shown to react with decreased inhibitory effect to histamine. 2 patients in this study had the HLA-B12 phenotype and systemic mastocytosis with high histamine turnover, but these patients reacted with a low mitogen response of the lymphocytes.
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