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  • Title: The main immunogenic region of acetylcholine receptors does not provoke the formation of antibodies of a predominant idiotype.
    Author: Killen JA, Hochschwender SM, Lindstrom JM.
    Journal: J Neuroimmunol; 1985 Aug; 9(3-4):229-41. PubMed ID: 4019748.
    Abstract:
    Anti-idiotype antibodies were induced in rats by immunization with rat monoclonal antibodies to the main immunogenic region of acetylcholine receptors. These anti-idiotype antibodies showed very little crossreaction with other rat monoclonal antibodies which bind to the same region of the receptor. When the rats producing these anti-idiotype antibodies were immunized with receptor, they showed no net decrease in anti-receptor antibody production. These data indicate that, although more than half of the antibodies produced by rats immunized with receptor are directed at a small region, many anti-receptor idiotypes are involved in this response and anti-idiotype therapy is not beneficial.
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