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  • Title: Chlamydia trachomatis infection in women.
    Author: Faro S.
    Journal: J Reprod Med; 1985 Mar; 30(3 Suppl):273-8. PubMed ID: 4020784.
    Abstract:
    Chlamydia trachomatis is found worldwide and is probably the most common sexually transmitted disease, infecting both females and males, adults as well as children. The organism is responsible for a variety of infections in women--urethral syndrome, cervicitis, endometritis and salpingitis. C. trachomatis may colonize the lower genital tract and result in asymptomatic infection, ultimately resulting in sterility. In addition, infection of the female genital tract during pregnancy may result in spontaneous abortion, premature labor, postpartum endometritis, neonatal conjunctivitis or pneumonia. Chlamydia trachomatis, considered the most common sexually transmitted organism, is responsible for a variety of infections in women, including urethral syndrome, cervicitis, endometritis, and salpingitis. It may colonize the lower genital tract and result in asymptomatic infection, ultimately resulting in sterility. An estimated 20-40% of sexually active women have been exposed to Chlamydia, and 4-5% of sexually active US women are estimated to carry Chlamydia in the cervix. Infection may involve the lower genital tract (bartholinitis, cervicitis, acute urethral syndrome), the upper genital tract (endometritis, salpingitis, Fitz-Hugh-Curtis syndrome), or both. However, the principal focus of infection appears to be the cervix. The maternal carriage rate of C. trachomatis ranges between 2-30%. Infection of the female genital tract during pregnancy may result in spontaneous abortion, premature labor, postpartum endometritis, neonatal conjunctivitis, or pneumonia. All women suspected of being colonized by or exposed to C. trachomatis should be evaluated throughly, and treatment should be administered to both the patient and her sexual partner. Since patients with 1 sexually transmitted disease are likely to have another, these women should be screened for Trichomonas, gonorrhea, syphilis, and herpes as well. The recommended treatment for nonpregnant women with C. trachomatis is 500 mg tetracycline 4 times/day, 50 mg minocycline 2 times/day, or 100 mg doxycycline 2 times/day.
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