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  • Title: Structural proteins of the opaque muscle fibers in Duchenne muscular dystrophy.
    Author: Uchino M, Araki S, Yoshida O, Uekawa K.
    Journal: Neurology; 1985 Sep; 35(9):1364-7. PubMed ID: 4022387.
    Abstract:
    We studied the structural proteins of the "opaque fibers" (OFs) in muscle biopsies from 12 patients, aged 4 to 24 years, with Duchenne muscular dystrophy. The electrophoretic patterns of myofibrillar proteins indicated three groups of opaque fibers: the first (OF a) had an almost normal electrophoretogram, the second (OF b1) showed a clear decrease of 55,000 dalton protein (desmin), and the third (OF b2) exhibited a great reduction in alpha-actinin and desmin. The data suggest that some OFs are pathologic fibers in the degenerative process of Duchenne dystrophy.
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