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  • Title: A comparison of in vivo and in vitro amphetamine on the synaptosomal uptake of dopamine in mouse striatum.
    Author: Hadfield MG.
    Journal: Res Commun Chem Pathol Pharmacol; 1985 May; 48(2):183-8. PubMed ID: 4023407.
    Abstract:
    Amphetamine (AMPH) produced competitive uptake inhibition of 3H-dopamine (DA) in synaptosomes obtained from mouse striatum--whether it was injected beforehand into living animals or simply added to the incubation medium. However, the in vivo drug doses required to produce this effect were high (ED50 = 65 mg/kg.) as compared with the in vitro doses (ED50 = 2.5 X 10(-6) M).
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