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  • Title: Teratogenesis study of dioxane in rats.
    Author: Giavini E, Vismara C, Broccia ML.
    Journal: Toxicol Lett; 1985 Jul; 26(1):85-8. PubMed ID: 4024160.
    Abstract:
    The industrial solvent dioxane (1,4-diethylene dioxide) was evaluated for teratogenic potential in Sprague-Dawley rats. The compound was administered on days 6-15 of gestation by gavage (0, 0.25, 0.5 and 1.0 ml/kg/day). A slight maternal toxicity, as evidenced by reduced weight gain, was observed with 1.0 ml/kg. Animals were killed and subjected to uterine examination on day 21 of pregnancy. There were no differences between control and dioxane-treated groups in implantation numbers, live fetuses, postimplantation loss or major malformations. Embryotoxicity, manifested by reduced fetal weight, occurred only at the highest dose level.
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