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  • Title: Histaminase release from human eosinophils.
    Author: Zeiger RS, Colten HR.
    Journal: J Immunol; 1977 Feb; 118(2):540-3. PubMed ID: 402420.
    Abstract:
    Phagocytosis of opsonized zymosan by human eosinophils results in a dose-dependent noncytotoxic release of histaminase as well as arylsulfatase and beta-glucuronidase. The calcium ionophore A23187 also stimulates release of eosinophil histaminase at concentrations of ionophore which barely release arylsulfatase and beta-glucuronidase. Zymosan-induced histaminase release from eosinophils but not from neutrophils was abolished or markedly reduced in the presence of cytochalasin B, suggesting a difference in the mechanisms of histaminase release from the two granulocyte cell types.
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