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  • Title: Inhibition of carnitine acetyltransferase by metabolites of 4-pentenoic acid.
    Author: Zhong J, Fong JC, Schulz H.
    Journal: Arch Biochem Biophys; 1985 Aug 01; 240(2):524-9. PubMed ID: 4026294.
    Abstract:
    The inhibition of carnitine acetyltransferase (EC 2.3.1.7) by metabolites of 4-pentenoic acid was studied. 3-Keto-4-pentenoyl-CoA, a beta-oxidation metabolite of 4-pentenoic acid, was found to be an effective inhibitor of the enzyme in the presence, but not in the absence of L-carnitine. Since acetyl-CoA protects the enzyme against this inhibition, 3-keto-4-pentenoyl-CoA seems to be an active site-directed inhibitor. 3-Keto-4-pentenoyl-CoA, which is a substrate of carnitine acetyltransferase, causes the irreversible inactivation of the enzyme. All observations together lead to the suggestion that 3-keto-4-pentenoyl-CoA is a mechanism-based inhibitor of carnitine acetyltransferase.
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