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  • Title: Atropine blockade of nerve-mediated stimulation of the human detrusor.
    Author: Kinder RB, Mundy AR.
    Journal: Br J Urol; 1985 Aug; 57(4):418-21. PubMed ID: 4027512.
    Abstract:
    The effect of atropine on the isometric contractile response of isolated human detrusor muscle strips to electrical field stimulation has been studied. A 94.1% reduction in the response in the presence of tetrodotoxin demonstrated the neuronal nature of the stimulus. Atropine caused a 92.7% inhibition of the response. It was concluded that the nerve-mediated stimulus in human detrusor is cholinergic in nature and that "atropine resistance" does not occur in man.
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