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Title: In vitro dopamine biosynthesis in the median eminence of rat hypothalamic slices: possible involvement of a Na+-Ca2+ exchange mechanism. Author: Arita J, Kimura F. Journal: Brain Res; 1985 Jul 15; 338(2):384-6. PubMed ID: 4027604. Abstract: Equimolar replacement of Na+ in medium with choline chloride or sucrose and experimental manipulations known to increase [Na+]i, such as ouabain addition and K+ deprivation from medium, caused a marked increase in in vitro DOPA synthesis in the median eminence of rat hypothalamic slices in a Ca2+-dependent manner. These results suggest that a Na+-Ca2+ exchange mechanism is closely involved in the regulation of dopamine biosynthesis in tuberoinfundibular neurons.[Abstract] [Full Text] [Related] [New Search]