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  • Title: Red cell pyruvate kinase deficiency: adverse effect of oral contraceptives.
    Author: Kendall AG, Charlow GF.
    Journal: Acta Haematol; 1977; 57(2):116-20. PubMed ID: 402766.
    Abstract:
    Erythrocyte enzymopathies are being detected with increasing frequency. The homozygous state for pyruvate kinase (PK) deficiency usually causes chronic non-spherocytic haemolytic anaemia. Aggravation of the condition by a variety of extrinsic factors has been reported, but drugs have rarely been incriminated. A case of severe PK deficiency is presented in which an anovulant drug upsets the usual haematologic balance. This strengthens the suspicion that contraceptive pills may be hazardous in such patients.
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