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  • Title: Prognostic relevance of ploidy, proliferation, and resistance-predictive tests in ovarian carcinoma.
    Author: Volm M, Brüggemann A, Günther M, Kleine W, Pfleiderer A, Vogt-Schaden M.
    Journal: Cancer Res; 1985 Oct; 45(10):5180-5. PubMed ID: 4027994.
    Abstract:
    In a cooperative study specimens of 37 patients with stage III and IV ovarian carcinomas who had been treated with chemotherapy were investigated utilizing flow cytometry and an in vitro short-term test for predicting resistance. Patients with aneuploid tumors had significantly shorter survival rates than did those with diploid tumors. Patients whose tumors showed a low G0/G1 cell proportion or a high proliferation pool (S- and G2/M cell-proportion) seemed to die earlier. There was also a tendency for patients with in vitro resistant tumors to die earlier under chemotherapy than those with sensitive tumors.
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