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  • Title: Insect sting anaphylaxis in patients without detectable serum venom-specific IgE.
    Author: Clayton WF, Georgitis JW, Reisman RE.
    Journal: Clin Allergy; 1985 Jul; 15(4):329-33. PubMed ID: 4028387.
    Abstract:
    Following insect sting anaphylaxis, twenty-five patients of over 500 evaluated, did not have detectable serum venom-specific IgE. Twenty-two were evaluated within 1 year of the reaction, fifteen within 6 months. Anaphylaxis occurred in six patients after their first sting exposure. The clinical features of the sting reaction were typical of the reaction occurring in insect-allergic patients with serum venom-specific IgE. Eleven of the twenty-five patients had negative venom skin tests. These observations suggest that a non-IgE mechanism may be responsible for a minority of insect sting reactions.
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