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  • Title: The lymphoproliferating cells of MRL-lpr/lpr mice are a polyclonal population that bear the T lymphocyte receptor for antigen.
    Author: Nemazee DA, Studer S, Steinmetz M, Dembić Z, Kiefer M.
    Journal: Eur J Immunol; 1985 Aug; 15(8):760-4. PubMed ID: 4029256.
    Abstract:
    Mice bearing the recessive gene lpr develop an age-dependent, massive lymphoproliferation, primarily in the lymph nodes (LN), with associated autoimmunity. LN cells from these mice express T cell receptor protein on the cell surface at 50-70% of normal levels. Normal levels of T cell receptor alpha, beta and gamma mRNA were found in these cells as compared to normal LN cells. Southern blot analysis of MRL-lpr/lpr LN DNA showed rearrangements in 80-90% of the chromosomes at the beta gene loci. The pattern of rearrangement indicated that a polyclonal rather than monoclonal expansion of T cells occurred. These data support a lymphokine-induction model of lymphoproliferation in MRL-lpr mice.
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