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  • Title: Deposition of type X collagen in the cartilage extracellular matrix.
    Author: Cancedda R, Capasso O, Castagnola P, Descalzi-Cancedda F, Quarto N.
    Journal: J Cell Biochem; 1985; 28(1):7-14. PubMed ID: 4030902.
    Abstract:
    In cultured chick embryo chondrocytes, type X collagen is preferentially deposited in the extracellular matrix, the ratio between type II and type X collagen being about 5 times higher in the culture medium than in the cell layer. When the newly synthesized collagens deposited in slices from the epiphyseal cartilage of 17-day-old embryo tibiae were isolated, type X collagen was always the major species. In agreement with this result the mRNA for type X collagen was the predominant mRNA species purified from the same tissue. When the total collagen (unlabeled) deposited in the epiphyseal cartilage was analyzed, it was observed that type X collagen represented only 1/15 of the type II collagen recovered in the same preparation. The possible explanations for these differences are discussed.
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