These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Aldose reductase and sorbitol dehydrogenase distribution in substructures of normal and diabetic rat lens.
    Author: Collins JG, Corder CN.
    Journal: Invest Ophthalmol Vis Sci; 1977 Mar; 16(3):242-3. PubMed ID: 403152.
    Abstract:
    Aldose reductase (AR) and sorbitol dehydrogenase (SDH) make up the sorbitol pathway, which has been implicated in the pathogenesis of sugar cataracts. The levels of the two enzymes were determined with quantitative histochemical techniques in the epithelium, cortex, and nucleus of normal and diabetic rat lenses. The ratio of activity of AR to SDH was found to be nearly 50 to 1 in all substructures. This would strongly favor sorbitol accumulation and subsequent cataract formation.
    [Abstract] [Full Text] [Related] [New Search]