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  • Title: Regeneration of axolotl hindlimbs bearing surgically created discontinuities in the anterior-posterior axis.
    Author: Holder N, Weekes C.
    Journal: J Embryol Exp Morphol; 1985 Apr; 86():283-310. PubMed ID: 4031745.
    Abstract:
    The pattern regulation process in amphibian limbs has been examined with respect to the presence of discontinuities in the anterior-posterior (a-p) axis. Limbs bearing such discontinuities were surgically created by contralateral exchange of either dorsal or ventral half thighs and these limbs were then amputated immediately after surgery. The results demonstrate that a-p discontinuities lead to the formation of extra limb structures during distal outgrowth in contrast to the mosaic behaviour of comparable limb stumps which contain dorsal-ventral (d-v) discontinuities (Holder & Weekes, 1984). It is evident, therefore, that pattern regulation in the transverse limb axes is accomplished by basically different mechanisms. The structure of the limbs in the present study was examined in Victoria-blue-stained wholemounts and serial sections. The results allow some discussion of the basic mechanisms for pattern regulation in the two transverse limb axes and the relationship between them.
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