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  • Title: Age-dependent variations of lysosomal enzymes in human liver.
    Author: Minami R, Sato S, Kudoh T, Oyanagi K, Nakao T.
    Journal: Tohoku J Exp Med; 1979 Sep; 129(1):65-70. PubMed ID: 40322.
    Abstract:
    The specific activities, the Km values, and the elution patterns on DEAE 52 and Sephadex G-150 columns of six lysosomal enzymes in human liver during development were studied. The levels of total beta-D-glucuronidase and N-acetyl-beta-D-glucosaminidase activities in childhood liver were higher than those in fetal liver. The Km values of beta-D-glucuronidase and beta-D-galactosidase in fetal liver were about ten times higher than those in childhood liver. The elution patterns on DEAE 52 of beta-D-glucuronidase and on Sephadex G-150 of alpha-D- and beta-D-galactosidases changed with aging. It is suggested that lysosomal enzymes related to degradation of gangliosides and glycosaminoglycans change during development.
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