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  • Title: New cysteamine (2-chloroethyl)nitrosoureas. Synthesis and preliminary antitumor results.
    Author: Madelmont JC, Godeneche D, Parry D, Duprat J, Chabard JL, Plagne R, Mathe G, Meyniel G.
    Journal: J Med Chem; 1985 Sep; 28(9):1346-50. PubMed ID: 4032435.
    Abstract:
    Three chemical pathways were used for the synthesis of four new N'-(2-chloroethyl)-N-[2-(methylsulfinyl)ethyl]- and N'-(2-chloroethyl)-N-[2-(methylsulfonyl)ethyl]-N- or N'-nitrosoureas. These compounds are plasma metabolites of CNCC, a promising antineoplastic (2-chloroethyl)nitrosourea. Preliminary antitumor evaluation was performed against L1210 leukemia implanted intraperitoneally in mice. Among these compounds, two of them exhibited a greater antitumor activity compared to that of the parent mixture.
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