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  • Title: Synthesis of alpha-aminomethyl derivatives of beta-phenyltetrahydrofuran-2-one.
    Author: Jakóbiec T, Zabska R, Sedzimirska B.
    Journal: Pol J Pharmacol Pharm; 1985; 37(1):73-7. PubMed ID: 4034438.
    Abstract:
    beta-Phenyltetrahydrofuran-2-one-alpha-carboxylic acid 1 was transformed in the Mannich reaction into alpha-aminomethyl derivatives of beta-phenyltetrahydrofuran-2-one 2-6. The obtained alpha-aminomethyllactones, in reaction of ammono- and hydrazinolysis yield alpha-aminomethyl-beta-phenyl gamma-hydroxybutyric acid derivatives 7-12. Compounds 4, 5, 8, 9, and 10 depress the central nervous system, and compound 12 shows analgesic properties.
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