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  • Title: Effects of two antihistaminic compounds (mequitazine, dexchlorpheniramine) on sleep. Sleep distorsion by antihistaminics.
    Author: Bassano JL, Caille EJ.
    Journal: Waking Sleeping; 1979 Jan; 3(1):57-61. PubMed ID: 40345.
    Abstract:
    Twelve healthy subjects have been given mequitazine (two 10-milligramme doses a day), dexchlorpheniramine (two 12-milligramme doses a day) and a placebo for seven days, within a cross-over balanced design. If dexchlorpheniramine induces a significant sleep distortion (slowed REM sleep cycle and decreased amount of REM sleep), no similar trend occured with mequitazine, a result that could be dose or time related.
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