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  • Title: Suppositories containing cyclodextrin complexes. Part 2: Dissolution and absorption studies.
    Author: Szente L, Apostol I, Gerlóczy A, Szejtli J.
    Journal: Pharmazie; 1985 Jun; 40(6):406-7. PubMed ID: 4034649.
    Abstract:
    The dissolution and absorption of poorly water-soluble drugs from rectal suppositories can be enhanced by complexing these substances (e.g., essential oils, indomethacin) with beta-cyclodextrin. Preliminary in vivo studies showed, that the application of cyclodextrin complexes to suppositories, the same as to oral applications, resulted in an increased blood level.
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