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  • Title: The ovarian enzyme catalyzing conversion of 13,14-dihydro-15-ketoprostaglandin F2 alpha to 13,14-dihydroprostaglandin F2 alpha in rats.
    Author: Inazu N, Kogo H, Satoh T.
    Journal: Res Commun Chem Pathol Pharmacol; 1985 Jul; 49(1):149-52. PubMed ID: 4035077.
    Abstract:
    The preliminary experiments concerning enzymes involved in the production system of 13,14-dihydroprostaglandin F2 alpha (13,14H2-PGF2 alpha) in rat ovary were carried out. The enzyme which converted 13,14-dihydro-15-keto-prostaglandin F2 alpha (15KD-PGF2 alpha) to 13,14H2-PGF2 alpha required NADPH as a cofactor, and the enzyme activity was inhibited by sulfhydryl reagents as well as quercitrin. Thus, the enzyme studied here seems to be a carbonyl reductase possessing SH group(s) in the molecule.
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