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  • Title: [Flunarizine in the treatment of arteriopathies of the legs].
    Author: Catalano M, Sacchi E, Tomasini M, Coazzoli E, Parolini A, Dall'Oglio A, Libretti A.
    Journal: Ric Clin Lab; 1985; 15 Suppl 1():475-8. PubMed ID: 4035228.
    Abstract:
    Flunarizine, a long-acting calcium antagonist, was studied in patients with peripheral vascular disease in order to assess its effects on blood viscosity, erythrocyte deformability, platelet activity and some clinical parameters. A randomized double-blind study was performed; all patients were given a standard diet, invited to abstain from smoking and to carry out a regular daily exercise (walking). After a 2-month run-in period the patients were divided into two groups: one was treated with flunarizine 10 mg/day and the other with placebo. The group treated with flunarizine presented marked and significant reduction of erythrocyte filtration time and blood viscosity and an improvement of the treadmill-free interval with a correlation between the parameters considered.
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