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  • Title: The effect of cholecystectomy on bile reflux. An experimental study.
    Author: Demetriades D.
    Journal: S Afr Med J; 1985 Aug 17; 68(4):235-8. PubMed ID: 4035477.
    Abstract:
    In an experimental study the effect of cholecystectomy on bile reflux into the stomach was investigated. Five dogs were used and a large number of bile reflux measurements carried out (115 tests). During each test, reflux was measured over a continuous period of 6 hours by estimating the concentration of bile phospholipids (lecithin and lysolecithin) in the gastric juice. The pre-cholecystectomy phospholipid concentration in the stomach was 7,751 +/- 1,621 mg/dl (mean +/- SEM) and the post-cholecystectomy concentration 35,181 +/- 10,653 mg/dl (P less than 0,05). Two dogs developed gastric mucosal changes, mainly foveolar hyperplasia. The importance of measuring reflux repeatedly over long periods of time in order to get a more representative picture of reflux is stressed.
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