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  • Title: Radioimmunoassay and characterization of woodchuck hepatitis virus core antigen and antibody.
    Author: Ponzetto A, Cote PJ, Ford EC, Engle R, Cicmanec J, Shapiro M, Purcell RH, Gerin JL.
    Journal: Virus Res; 1985 Jun; 2(4):301-15. PubMed ID: 4036315.
    Abstract:
    Solid-phase radioimmunoassays for woodchuck hepatitis virus core antigen (WHcAg) and antibody (anti-WHc) were developed. WHcAg in woodchuck liver homogenates was characterized by ultracentrifugation in CsCl gradients; both heavy (1.35 g/cm3) and light (1.31 g/cm3) cores were obtained from the liver of an animal during acute WHV infection, which is consistent with observations in hepatitis B virus infection in man. Endpoint titers of anti-WHc were higher in chronic WHV carriers than in animals recovered from acute infections. Both IgM and IgG anti-WHc antibodies were produced by infected woodchucks. A survey of colony woodchucks demonstrated that 88/89 animals having one or more markers of past or ongoing WHV infection were positive for anti-WHc. Thus, serum anti-WHc appears to be a sensitive marker of WHV infection.
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