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  • Title: [The use of dimethyl sulfoxide in the treatment of intractable urinary frequency].
    Author: Okamura K, Mizunaga M, Arima S, Tokunaka S, Inada F, Takamura T, Yachiku S.
    Journal: Hinyokika Kiyo; 1985 Apr; 31(4):627-31. PubMed ID: 4036738.
    Abstract:
    Intravesical instillation of dimethyl sulfoxide (DMSO) was used in the treatment of patients with intractable urinary frequency due to chronic prostatitis, chronic cystitis, tuberculous contracted bladder and interstitial cystitis. Before the application of this therapy, all 4 patients were examined carefully to rule out cases of acute infectious diseases of the urinary tract, active urinary tuberculosis, neurogenic bladder and carcinoma in situ of the bladder. Three of the four patients achieved an excellent response both subjectively and objectively. In the United States, intravesical instillation of DMSO had already been established as the specific method in the treatment of interstitial cystitis and no side effects have been reported so far. Therefore, we recommend the use of intravesical instillation of DMSO more commonly in various forms of intractable urinary frequency.
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