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  • Title: Fibrinolysis and acquired alpha-2 plasmin inhibitor deficiency in amyloidosis.
    Author: Meyer K, Williams EC.
    Journal: Am J Med; 1985 Sep; 79(3):394-6. PubMed ID: 4036990.
    Abstract:
    A patient with plasma cell myeloma and amyloidosis presented with a severe bleeding disorder. There was laboratory evidence of fibrinolysis and severe deficiency of alpha-2 plasmin inhibitor. Treatment with epsilon aminocaproic acid was associated with diminished bleeding and marked increase in the plasmin inhibitor level. This is the first report of acquired alpha-2 plasmin inhibitor deficiency in the fibrinolytic state associated with amyloidosis.
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