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  • Title: Antithrombin III concentrates for treatment of disseminated intravascular coagulation in children.
    Author: Hanada T, Abe T, Takita H.
    Journal: Am J Pediatr Hematol Oncol; 1985; 7(1):3-8. PubMed ID: 4037242.
    Abstract:
    Six children (1 month to 5 years old) with DIC were treated with bolus injection of AT-III concentrates and/or continuous heparin infusion. In one case, when AT-III concentrates were administered without heparin, the platelet count was normalized in accordance with a rise in the plasma AT-III level. In the other children, who were treated with both AT-III concentrates and heparin, most of the abnormalities in coagulation studies were normalized within 5 days in four of five cases. These findings suggest that the administration of AT-III concentrates may significantly enhance the therapeutic efficacy of heparin, and that the use of AT-III concentrates with heparin is a safe and effective regimen for the treatment of childhood DIC.
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