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  • Title: [Pneumopathies caused by hypersensitivity to amiodarone and associated nephropathies. Study by alveolar lavage].
    Author: Caubarrère I, Bonan G, Venet A, Chebat J, Uzzan D, Gilbert J, Beaufils H.
    Journal: Ann Med Interne (Paris); 1985; 136(4):311-5. PubMed ID: 4037586.
    Abstract:
    Four cases of amiodarone-induced restrictive, hypoxaemic lung disease are described. The cumulative dosages of amiodarone were relatively low (30 to 100 g). Alveolar lavage studies showed a lymphocytosis and study of the lymphocytic sub-populations showed an increase in the OKT8 group, and an inversion of the OKT4/OKT8 ratio. The outcome was favourable on withdrawal of amiodarone and steroid therapy. The immunological origin of this form of lung disease was confirmed. Two patients had renal failure; in the first case, hypercalcaemia, hyperphosphoremia and renal calcification were observed. The second patient had endo- and extracapillary glomerulonephritis with C3 deposits and circulating immune complexes. Renal failure regressed in both cases on withdrawal of amiodarone and with steroid therapy.
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