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  • Title: Mid-trimester therapeutic abortion by vaginal suppository of 16, 16-dimethyl-trans-delta 2-prostaglandin E1.
    Author: Kato K, Furuya K, Makimura N, Nagata I, Ishida M, Seki K.
    Journal: Asia Oceania J Obstet Gynaecol; 1985 Jun; 11(2):163-7. PubMed ID: 4038169.
    Abstract:
    A new analog of prostaglandin E1 (PGE1) was administered vaginally to women with (n=20) and without (n=29) laminaria tents and metreurynter for therapeutic abortion during the 2nd trimester. All patients aborted successfully. The abortion time was short, bleeding was minimal, and there was little difference between patients treated with 16 DM-PGE1 alone and those treated with 16 DM-PGE1, laminaria tents, and metreurynter. However, amounts of 16 DM-PGE1 required for abortion were significantly greater in patients treated with 16 DM-PGE1 alone. Occurrences of side effects increased with increased amounts of 16 DM-PGE1 administered. Therefore, vaginal administration of that in combination with the use of laminaria tents and metreurynter successfully induced abortion in women during the midtrimester with minimal side effects, and was considered to be the best method presently available for midtrimester therapeutic abortion.
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