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  • Title: Differential binding of glycine- and taurine-conjugated bile acids to insoluble calcium phosphate.
    Author: Van der Meer R, De Vries HT.
    Journal: Biochem J; 1985 Jul 01; 229(1):265-8. PubMed ID: 4038261.
    Abstract:
    It is demonstrated that bile acids bind to insoluble calcium phosphate at pH values beyond 5.5. Significant binding occurs with glycine-conjugated dihydroxy bile acids. Results indicate that these bile acids are bound in a micellar mode. Taurine conjugation almost completely inhibits the binding of these bile acids to insoluble calcium phosphate. Since glycine-conjugated dihydroxy bile acids are predominant in the rabbit, but not in the rat, our results suggest an explanation for the intriguing species-dependence of casein-induced hypercholesterolaemia, which is high in the rabbit but absent in the rat.
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