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  • Title: [Prevention of recurrence in urinary bladder tumors by intravesical instillation treatment with adriamycin].
    Author: Flamm J, Grof F.
    Journal: Urologe A; 1985 Jan; 24(1):31-5. PubMed ID: 4039083.
    Abstract:
    109 patients with urinary bladder cancer received post TUR treatment with weekly intravesical instillations of Adriamycin for a period of 6 weeks. 32 patients received a dosage of 10 mg/50 ml physiological NaCl, 35 patients a dosage of 30 mg/50 ml physiological NaCl. We determined the oncolytical value and the value of prophylactically reduced recurrence through urine cytology and endoscopic controls with biopsies. After an observation period of 1 year the result was the same in all groups; 13% had a persistent tumour, 71% remained recurrence free. By raising the dosage of Adriamycin we achieved a reduction in the persister rate from 31% with 10 mg/50 ml NaCl to 6% with 30 mg/50 ml NaCl and to 5% with 50 mg/50 ml NaCl. There was no significant correlation between dosage and recurrence rate. The recurrence rate after a dosage of 10 mg/50 ml was 31%, after 30 mg/50 ml 73% and after 50 mg/50 ml 33%. The increasing recurrence rate correlates with the intensity of local tumour infiltration and with the grading of the primary tumours.
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