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  • Title: The effect of pH on alkaline phosphatase activity in serum of the rat and other species.
    Author: Yabe T.
    Journal: Arzneimittelforschung; 1985; 35(1A):193-6. PubMed ID: 4039161.
    Abstract:
    Contrary to other species, optimum pH of alkaline phosphatase (alk.P.) activity was 9.6 in fed male rats of all age groups studies. In 3- or 6-week-old fasted rats, the optimum pH shifted to 9.8-10.0. This shifting of pH did not occur in 11-week-old rats. Heating to 56 degrees C for 10 min shifted the optimum pH in 3-week-old rats to 9.0, in 6-week-old rats to 9.0-9.4, but no change occurred in 11-week-old rats. In other species (mouse, rabbit, and man), the optimum pH was 10.0-10.2, and was not influenced by fasting or heating.
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