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  • Title: Comparison of the effects of nifedipine on ureter and coronary artery isolated from the dog.
    Author: Sakanashi M, Kato T, Miyamoto Y, Takeo S, Noguchi K, Ito H, Nakasone J, Aniya Y.
    Journal: Arzneimittelforschung; 1985; 35(3):584-7. PubMed ID: 4039584.
    Abstract:
    The effect of nifedipine (Adalat) on isolated dog ureter was compared with that on isolated coronary artery. Nifedipine at a concentration of 10(-8) mol/l significantly decreased the frequency of ureteral rhythmic contractions evoked by potassium, and suppressed the force of these contractions at a concentration of 3 X 10(-8) mol/l. In potassium-contracted coronary artery strips, nifedipine at concentrations more than 3 X 10(-9) mol/l produced significant relaxations in a concentration-dependent manner. The results indicate that nifedipine is able to act inhibitorily on ureteral contractions, and inhibition of pace making activities in ureteral smooth muscle was suggested as a mode of action of nifedipine.
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