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  • Title: Qualitative and quantitative changes of mouse cerebellar synapses after chronic alcohol consumption and withdrawal.
    Author: Phillips SC.
    Journal: Exp Neurol; 1985 Jun; 88(3):748-56. PubMed ID: 4039675.
    Abstract:
    For 4 months C57 mice were fed a nutritionally complete diet containing 9% alcohol or isocaloric sucrose and killed then or after 4 months recovery on standard food pellets. Electron microscopy was used to count synapses among the cerebellar Purkinje cell dendrites and a significant 13% reduction was found in the alcohol recovery group. The shape of the postsynaptic density material was studied and a significant 11% increase in length found in the alcohol group. The smaller thickness of the postsynaptic material in animals of the alcohol recovery group may be representative of new synaptic formation.
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