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  • Title: In vitro cisplatin effects on phagocyte functions.
    Author: Fumarulo R, Riccardi S, Pantaleo R, Coluccia M, Giordano D, Aresta M.
    Journal: Int J Cancer; 1985 Jun 15; 35(6):777-80. PubMed ID: 4040125.
    Abstract:
    The effects of cis-diamminedichloroplatinum (II) (cisplatin), a drug used in cancer chemotherapy, on the oxidative metabolism, endocytosis, chemotaxis and exocytosis of guinea-pig polymorphonuclear leukocytes were studied. All these functions were negatively influenced, but the same effect (50% inhibition) was observed at different drug concentrations (3 X 10(-5) M for chemotaxis, 10(-4) M for O2 consumption by FMLP and beta-glucuronidase release, 10(-3) M for O2 consumption by PMA and for zymosan engulfment). The effects of the drug can be explained by its ability to bind to membrane proteins, essentially to -SH groups.
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